GNRHR Antibody
| Code | Size | Price |
|---|
| PSI-59-795-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Gonadotropin-releasing hormone receptor, GnRH receptor, GnRH-R, GNRHR, GRHR
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes the receptor for type 1
gonadotropin-releasing hormone. This receptor is a member of the
seven-transmembrane, G-protein coupled receptor (GPCR) family. It
is expressed on the surface of pituitary gonadotrope cells as well
as lymphocytes, breast, ovary, and prostate. Following binding of
gonadotropin-releasing hormone, the receptor associates with
G-proteins that activate a phosphatidylinositol-calcium second
messenger system. Activation of the receptor ultimately causes the
release of gonadotropic luteinizing hormone (LH) and follicle
stimulating hormone (FSH). Defects in this gene are a cause of
hypogonadotropic hypogonadism (HH). Alternative splicing results in
multiple transcript variants encoding different isoforms. More than
18 transcription initiation sites in the 5' region and multiple
polyA signals in the 3' region have been identified for this gene.
Background References:
- Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
- Armstrong, S.P., et al. J. Biol. Chem. 285(32):24360-24371(2010)
- Lee, G., et al. Cancer Immunol. Immunother. 59(7):1011-1019(2010)
- Re, M., et al. PLoS ONE(7), E11489 (2010) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This GNRHR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-77 amino acids from the N-terminal region of human GNRHR.
NCBI Gene ID #:
2798
NCBI Official Name:
Gonadotropin-releasing hormone receptor
NCBI Official Symbol:
GNRHR
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
38 kDa
Protein Accession #:
P30968
Protein GI Number:
399777
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Growth Factor
Swissprot #:
P30968
User NOte:
Optimal dilutions for each application to be determined by the researcher.