Metabotropic Glutamate Receptor 1 Antibody
| Code | Size | Price |
|---|
| PSI-62-256-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Metabotropic glutamate receptor 1, mGluR1, GRM1, GPRC1A, MGLUR1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 (also known as GPRC1A) and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The activity of GRM1 is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. This protein may participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum
Background References:
- Hlavackova, V., et al., EMBO J. 24(3):499-509 (2005).
- Kammermeier, P.J., et al., J. Pharmacol. Exp. Ther. 312(2):502-508 (2005).
- Burgueno, J., et al., Exp. Cell Res. 300(1):23-34 (2004).
- Mundell, S.J., et al., Mol. Pharmacol. 65(6):1507-1516 (2004).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This Metabotropic Glutamate Receptor 1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1096-1126 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 1.
NCBI Gene ID #:
2911
NCBI Official Name:
Metabotropic glutamate receptor 1
NCBI Official Symbol:
GRM1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
132 kDa
Protein Accession #:
Q13255
Protein GI Number:
311033443
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Growth Factor
Swissprot #:
Q13255
User NOte:
Optimal dilutions for each application to be determined by the researcher.