PDE6A Antibody
| Code | Size | Price |
|---|
| PSI-56-928-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, GMP-PDE alpha, PDE V-B1, PDE6A, PDEA
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes the cyclic-GMP (cGMP)-specific
phosphodiesterase 6A alpha subunit, expressed in cells of the
retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a
heterotrimer composed of an alpha, beta, and two gamma subunits.
cGMP is an important regulator of rod cell membrane current, and
its dynamic concentration is established by phosphodiesterase 6A
cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein
is a subunit of a key phototransduction enzyme and participates in
processes of transmission and amplification of the visual signal.
Mutations in this gene have been identified as one cause of
autosomal recessive retinitis pigmentosa.
Background References:
- Clark, G.R., et al. Ophthalmology 117(11):2169-2177(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Perlis, R.H., et al. Biol. Psychiatry 67(11):1110-1113(2010)
- Bazhin, A.V., et al. Cell. Mol. Life Sci. 67(5):817-828(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This PDE6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDE6A.
NCBI Gene ID #:
5145
NCBI Official Name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
NCBI Official Symbol:
PDE6A
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
100 kDa
Protein Accession #:
P16499
Protein GI Number:
215274230
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P16499
User NOte:
Optimal dilutions for each application to be determined by the researcher.