MED26 Antibody
Code | Size | Price |
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PSI-58-474-400ul | 400ul | £626.00 |
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Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
Mediator of RNA polymerase II transcription subunit 26, Activator-recruited cofactor 70 kDa component, ARC70, Cofactor required for Sp1 transcriptional activation subunit 7, CRSP complex subunit 7, Mediator complex subunit 26, Transcriptional coactivator CRSP70, MED26, ARC70, CRSP7
Application Note:
For WB starting dilution is: 1:1000
Background:
The activation of gene transcription is a multistep
process that is triggered by factors that recognize transcriptional
enhancer sites in DNA. These factors work with co-activators to
direct transcriptional initiation by the RNA polymerase II
apparatus. The protein encoded by this gene is a subunit of the
CRSP (cofactor required for SP1 activation) complex, which, along
with TFIID, is required for efficient activation by SP1. This
protein is also a component of other multisubunit complexes e.g.
thyroid hormone receptor-(TR-) associated proteins which interact
with TR and facilitate TR function on DNA templates in conjunction
with initiation factors and cofactors.
Background References:
- Ding, N., et al. J. Biol. Chem. 284(5):2648-2656(2009)
- Olsen, J.V., et al. Cell 127(3):635-648(2006)
- Olsen, J.V., et al. Cell 127(3):635-648(2006)
- Zhang, X., et al. Mol. Cell 19(1):89-100(2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MED26 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-220 amino acids from the Central region of human MED26.
NCBI Gene ID #:
9441
NCBI Official Name:
Mediator of RNA polymerase II transcription subunit 26
NCBI Official Symbol:
MED26
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
65 kDa
Protein Accession #:
O95402
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
O95402
User NOte:
Optimal dilutions for each application to be determined by the researcher.