PNPLA6 Antibody
| Code | Size | Price |
|---|
| PSI-58-373-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Neuropathy target esterase, Patatin-like phospholipase domain-containing protein 6, PNPLA6, NTE
Application Note:
For WB starting dilution is: 1:1000
Background:
PNPLA6 is a phospholipase that deacetylates
intracellular phosphatidylcholine to produce glycerophosphocholine.
It is thought to function in neurite outgrowth and process
elongation during neuronal differentiation. The protein is anchored
to the cytoplasmic face of the endoplasmic reticulum in both
neurons and non-neuronal cells. Mutations in this gene result in
autosomal recessive spastic paraplegia, and the protein is the
target for neurodegeneration induced by organophosphorus compounds
and chemical warfare agents. Multiple transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].
Background References:
- Hein, N.D., et al. Toxicol. Lett. 199(1):1-5(2010)
- Chen, J.X., et al. Pharmacol. Res. 62(3):259-264(2010)
- Greiner, A.J., et al. Biochim. Biophys. Acta 1798(8):1533-1539(2010)
- Hein, N.D., et al. Toxicol. Lett. 196(2):67-73(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This PNPLA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1000-1029 amino acids from the C-terminal region of human PNPLA6.
NCBI Gene ID #:
10908
NCBI Official Name:
Neuropathy target esterase
NCBI Official Symbol:
PNPLA6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
150 kDa
Protein Accession #:
Q8IY17
Protein GI Number:
150403921
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
Q8IY17
User NOte:
Optimal dilutions for each application to be determined by the researcher.