MPZL2 Antibody
| Code | Size | Price |
|---|
| PSI-59-388-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Myelin protein zero-like protein 2, Epithelial V-like antigen 1, MPZL2, EVA, EVA1
Application Note:
For WB starting dilution is: 1:1000
Background:
Thymus development depends on a complex series of
interactions between thymocytes and the stromal component of the
organ. Epithelial V-like antigen (EVA) is expressed in thymus
epithelium and strongly downregulated by thymocyte developmental
progression. This gene is expressed in the thymus and in several
epithelial structures early in embryogenesis. It is highly
homologous to the myelin protein zero and, in thymus-derived
epithelial cell lines, is poorly soluble in nonionic detergents,
strongly suggesting an association to the cytoskeleton. Its
capacity to mediate cell adhesion through a homophilic interaction
and its selective regulation by T cell maturation might imply the
participation of EVA in the earliest phases of thymus
organogenesis. The protein bears a characteristic V-type domain and
two potential N-glycosylation sites in the extracellular domain; a
putative serine phosphorylation site for casein kinase 2 is also
present in the cytoplasmic tail. Two transcript variants encoding
the same protein have been found for this gene. [provided by
RefSeq].
Background References:
- Kim, H., et al. Pharmacogenomics 10(2):171-179(2009)
- Lamesch, P., et al. Genomics 89(3):307-315(2007)
- Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
- Guttinger, M., et al. J. Cell Biol. 141(4):1061-1071(1998)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MPZL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-94 amino acids from the Central region of human MPZL2.
NCBI Gene ID #:
10205
NCBI Official Name:
Myelin protein zero-like protein 2
NCBI Official Symbol:
MPZL2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
24 kDa
Protein Accession #:
O60487
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
O60487
User NOte:
Optimal dilutions for each application to be determined by the researcher.