WNT3 Antibody
| Code | Size | Price |
|---|
| PSI-57-501-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Proto-oncogene Wnt-3, Proto-oncogene Int-4 homolog, WNT3, INT4
Application Note:
For WB starting dilution is: 1:1000
Background:
The WNT gene family consists of structurally related genes
which encode secreted signaling proteins. These proteins have been
implicated in oncogenesis and in several developmental processes,
including regulation of cell fate and patterning during
embryogenesis. This gene is a member of the WNT gene family. It
encodes a protein which shows 98% amino acid identity to mouse Wnt3
protein, and 84% to human WNT3A protein, another WNT gene product.
The mouse studies show the requirement of Wnt3 in primary axis
formation in the mouse. Studies of the gene expression suggest that
this gene may play a key role in some cases of human breast,
rectal, lung, and gastric cancer through activation of the
WNT-beta-catenin-TCF signaling pathway. This gene is clustered with
WNT15, another family member, in the chromosome 17q21 region.
Background References:
- Nikopensius, T., et al. Birth Defects Res. PartClin. Mol. Teratol. 88(9):748-756(2010)
- Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
- Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
- Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Xenopus
Immunogen:
This WNT3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-184 amino acids from the Central region of human WNT3.
NCBI Gene ID #:
7473
NCBI Official Name:
Proto-oncogene Wnt-3
NCBI Official Symbol:
WNT3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
40 kDa
Protein Accession #:
P56703
Protein GI Number:
14424477
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P56703
User NOte:
Optimal dilutions for each application to be determined by the researcher.