CHM Antibody
| Code | Size | Price |
|---|
| PSI-60-861-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Rab proteins geranylgeranyltransferase component A 1, Choroideremia protein, Rab escort protein 1, REP-1, TCD protein, CHM, REP1, TCD
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes component A of the RAB geranylgeranyl
transferase holoenzyme. In the dimeric holoenzyme, this subunit
binds unprenylated Rab GTPases and then presents them to the
catalytic Rab GGTase subunit for the geranylgeranyl transfer
reaction. Rab GTPases need to be geranylgeranyled on either one or
two cysteine residues in their C-terminus to localize to the
correct intracellular membrane. Mutations in this gene are a cause
of choroideremia; also known as tapetochoroidal dystrophy (TCD).
This X-linked disease is characterized by progressive dystrophy of
the choroid, retinal pigment epithelium and retina. Alternative
splicing results in multiple transcript variants encoding different
isoforms.
Background References:
- Perez-Cano, H.J., et al. Am. J. Med. Genet.149A (10), 2134-2140 (2009) :
- Renner, A.B., et al. Arch. Ophthalmol. 127(7):907-912(2009)
- Sergeev, Y.V., et al. Mutat. Res. 665 (1-2), 44-50 (2009) :
- MacDonald, I.M., et al. Surv Ophthalmol 54(3):401-407(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CHM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-320 amino acids from the Central region of human CHM.
NCBI Gene ID #:
1121
NCBI Official Name:
Rab proteins geranylgeranyltransferase component A 1
NCBI Official Symbol:
CHM
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
73 kDa
Protein Accession #:
P24386
Protein GI Number:
21431807
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P24386
User NOte:
Optimal dilutions for each application to be determined by the researcher.