GTPBP3 Antibody

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ProSci
Product Code: PSI-60-598
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-60-598-400ul400ul£626.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).

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Further Information

Additional Names:
tRNA modification GTPase GTPBP3, mitochondrial, GTP-binding protein 3, Mitochondrial GTP-binding protein 1, GTPBP3, MTGP1
Application Note:
For WB starting dilution is: 1:1000
Background:
This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described.
Background References:
  • Reiling, E., et al. Eur. J. Hum. Genet. 17(8):1056-1062(2009)
  • Villarroya, M., et al. Mol. Cell. Biol. 28(24):7514-7531(2008)
  • Bykhovskaya, Y., et al. Mol. Genet. Metab. 83(3):199-206(2004)
  • Li, X., et al. Biochem. Biophys. Res. Commun. 312(3):747-754(2003)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This GTPBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-320 amino acids from the Central region of human GTPBP3.
NCBI Gene ID #:
84705
NCBI Official Name:
tRNA modification GTPase GTPBP3, mitochondrial
NCBI Official Symbol:
GTPBP3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
52 kDa
Protein Accession #:
Q969Y2
Protein GI Number:
313104112
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
Q969Y2
User NOte:
Optimal dilutions for each application to be determined by the researcher.