NARF Antibody
| Code | Size | Price |
|---|
| PSI-59-132-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Nuclear prelamin A recognition factor, Iron-only hydrogenase-like protein 2, IOP2, NARF
Application Note:
For WB starting dilution is: 1:1000
Background:
Several proteins have been found to be prenylated and
methylated at their carboxyl-terminal ends. Prenylation was
initially believed to be important only for membrane attachment.
However, another role for prenylation appears to be its importance
in protein-protein interactions. The only nuclear proteins known to
be prenylated in mammalian cells are prelamin A- and B-type lamins.
Prelamin A is farnesylated and carboxymethylated on the cysteine
residue of a carboxyl-terminal CaaX motif. This
post-translationally modified cysteine residue is removed from
prelamin A when it is endoproteolytically processed into mature
lamin A. The protein encoded by this gene binds to the prenylated
prelamin A carboxyl-terminal tail domain. It may be a component of
a prelamin A endoprotease complex. The encoded protein is located
in the nucleus, where it partially colocalizes with the nuclear
lamina. It shares limited sequence similarity with iron-only
bacterial hydrogenases. Alternatively spliced transcript variants
encoding different isoforms have been identified for this gene,
including one with a novel exon that is generated by RNA editing.
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Moller-Krull, M., et al. J. Mol. Biol. 382(3):601-609(2008)
- Melzer, D., et al. PLoS Genet.(5), E1000072 (2008) :
- Lattanzi, G., et al. J. Cell. Biochem. 102(5):1149-1159(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This NARF antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-160 amino acids from the Central region of human NARF.
NCBI Gene ID #:
26502
NCBI Official Name:
Nuclear prelamin A recognition factor
NCBI Official Symbol:
NARF
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
51 kDa
Protein Accession #:
Q9UHQ1
Protein GI Number:
74735021
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
Q9UHQ1
User NOte:
Optimal dilutions for each application to be determined by the researcher.