RAPGEF5 Antibody
| Code | Size | Price |
|---|
| PSI-58-923-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Rap guanine nucleotide exchange factor 5, Guanine nucleotide exchange factor for Rap1, M-Ras-regulated Rap GEF, MR-GEF, Related to Epac, Repac, RAPGEF5, GFR, KIAA0277, MRGEF
Application Note:
For WB starting dilution is: 1:1000
Background:
Members of the RAS (see HRAS; MIM 190020) subfamily of
GTPases function in signal transduction as GTP/GDP-regulated
switches that cycle between inactive GDP- and active GTP-bound
states. Guanine nucleotide exchange factors (GEFs), such as
RAPGEF5, serve as RAS activators by promoting acquisition of GTP to
maintain the active GTP-bound state and are the key link between
cell surface receptors and RAS activation (Rebhun et al., 2000
[PubMed 10934204]).
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)
- Hwang, S.J., et al. BMC Med. Genet.SUPPL 1, S10 (2007) :
- Rebhun, J.F., et al. J. Biol. Chem. 275(45):34901-34908(2000)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This RAPGEF5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 529-555 amino acids from the C-terminal region of human RAPGEF5.
NCBI Gene ID #:
9771
NCBI Official Name:
Rap guanine nucleotide exchange factor 5
NCBI Official Symbol:
RAPGEF5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
68 kDa
Protein Accession #:
Q92565
Protein GI Number:
32171396
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
Q92565
User NOte:
Optimal dilutions for each application to be determined by the researcher.