CLDN14 Antibody
| Code | Size | Price |
|---|
| PSI-60-829-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Claudin-14, CLDN14
Application Note:
For WB starting dilution is: 1:1000
Background:
Tight junctions represent one mode of cell-to-cell
adhesion in epithelial or endothelial cell sheets, forming
continuous seals around cells and serving as a physical barrier to
prevent solutes and water from passing freely through the
paracellular space. These junctions are comprised of sets of
continuous networking strands in the outwardly facing cytoplasmic
leaflet, with complementary grooves in the inwardly facing
extracytoplasmic leaflet. The protein encoded by this gene, a
member of the claudin family, is an integral membrane protein and a
component of tight junction strands. The encoded protein also binds
specifically to the WW domain of Yes-associated protein. Defects in
this gene are the cause of an autosomal recessive form of
nonsyndromic sensorineural deafness. It is also reported that four
synonymous variants in this gene are associated with kidney stones
and reduced bone mineral density. Several transcript variants
encoding the same protein have been found for this gene. [provided
by RefSeq].
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Thorleifsson, G., et al. Nat. Genet. 41(8):926-930(2009)
- Belguith, H., et al. Biochem. Biophys. Res. Commun. 385(1):1-5(2009)
- Lal-Nag, M., et al. Genome Biol. 10 (8), 235 (2009) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This CLDN14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the C-terminal region of human CLDN14.
NCBI Gene ID #:
23562
NCBI Official Name:
Claudin-14
NCBI Official Symbol:
CLDN14
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
26 kDa
Protein Accession #:
O95500
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
O95500
User NOte:
Optimal dilutions for each application to be determined by the researcher.