PKP2 Antibody
| Code | Size | Price |
|---|
| PSI-56-747-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Plakophilin-2, PKP2
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a member of the arm-repeat (armadillo)
and plakophilin gene families. Plakophilin proteins contain
numerous armadillo repeats, localize to cell desmosomes and nuclei,
and participate in linking cadherins to intermediate filaments in
the cytoskeleton. This gene product may regulate the signaling
activity of beta-catenin. Two alternately spliced transcripts
encoding two protein isoforms have been identified. A processed
pseudogene with high similarity to this locus has been mapped to
chromosome 12p13.
Background References:
- Fressart, V., et al. Europace 12(6):861-868(2010)
- Cox, M.G., et al. Circ Arrhythm Electrophysiol 3(2):126-133(2010)
- Christensen, A.H., et al. Cardiology 115(2):148-154(2010)
- den Haan, A.D., et al. Circ Cardiovasc Genet 2(5):428-435(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PKP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 838-866 amino acids from the C-terminal region of human PKP2.
NCBI Gene ID #:
5318
NCBI Official Name:
Plakophilin-2
NCBI Official Symbol:
PKP2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
97 kDa
Protein Accession #:
Q99959
Protein GI Number:
296452867
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
Q99959
User NOte:
Optimal dilutions for each application to be determined by the researcher.