LIN7C Antibody

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ProSci
Product Code: PSI-56-659
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-56-659-400ul400ul£626.00
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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LIN7C Antibdy immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LIN7C Antibdy for immunohistochemistry.
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Western blot analysis in MCF-7,NCI-H292 cell line lysates (35ug/lane).
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LIN7C Antibdy immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of LIN7C Antibdy for immunohistochemistry.
Western blot analysis in MCF-7,NCI-H292 cell line lysates (35ug/lane).

Documents

Further Information

Additional Names:
Protein lin-7 homolog C, Lin-7C, Mammalian lin-seven protein 3, MALS-3, Vertebrate lin-7 homolog 3, Veli-3, LIN7C, MALS3, VELI3
Application Note:
For IHC-P starting dilution is: 1:10~50

For WB starting dilution is: 1:1000
Background:
LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
Background References:
  • Ng, M.C., et al. J. Clin. Endocrinol. Metab. 95(5):2418-2425(2010)
  • Lanktree, M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 147B (6), 945-951 (2008) :
  • Bulgin, N.L., et al. Neuromolecular Med. 10(4):343-355(2008)
  • Onda, T., et al. Cancer Res. 67(20):9643-9648(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Immunogen:
This LIN7C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human LIN7C.
NCBI Gene ID #:
55327
NCBI Official Name:
Protein lin-7 homolog C
NCBI Official Symbol:
LIN7C
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
22 kDa
Protein Accession #:
Q9NUP9
Protein GI Number:
59798474
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
Q9NUP9
User NOte:
Optimal dilutions for each application to be determined by the researcher.