RLN1/RLN2 Antibody
| Code | Size | Price |
|---|
| PSI-57-316-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Prorelaxin H1, Relaxin B chain, Relaxin A chain, RLN1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Relaxins are known endocrine and autocrine/paracrine
hormones, belonging to the insulin gene superfamily. In the human
there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3.
RLN1 and RLN2 share high sequence homology. This encoded protein is
synthesized as a single-chain polypeptide but the active form
consists of an A chain and a B chain linked by disulfide bonds;
however, their exact cleavage sites have not been described.
Relaxin is produced by the ovary, and targets the mammalian
reproductive system to ripen the cervix, elongate the pubic
symphysis and inhibit uterine contraction. It may have additional
roles in enhancing sperm motility, regulating blood pressure,
controlling heart rate and releasing oxytocin and vasopressin. This
gene has multiple polyadenylation sites. There are multiple
alternatively spliced transcript variants described for this gene
but their full length nature is not known yet. [provided by
RefSeq].
Background References:
- Radestock, Y., et al. Mol. Cancer Res. 8(4):494-506(2010)
- Davila, S., et al. Genes Immun. 11(3):232-238(2010)
- Ferlin, A., et al. Bone 46(2):504-513(2010)
- Vogel, I., et al. In Vivo 23(6):1005-1009(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This RLN1/RLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-165 amino acids from the C-terminal region of human RLN1/RLN2.
NCBI Gene ID #:
6013
NCBI Official Name:
Prorelaxin H1
NCBI Official Symbol:
RLN1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
21 kDa
Protein Accession #:
P04808
Protein GI Number:
132280
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P04808
User NOte:
Optimal dilutions for each application to be determined by the researcher.