PCDHGA1 Antibody
| Code | Size | Price |
|---|
| PSI-55-970-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Protocadherin gamma-A1, PCDH-gamma-A1, PCDHGA1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene is a member of the protocadherin gamma gene
cluster, one of three related clusters tandemly linked on
chromosome five. These gene clusters have an immunoglobulin-like
organization, suggesting that a novel mechanism may be involved in
their regulation and expression. The gamma gene cluster includes 22
genes divided into 3 subfamilies. Subfamily A contains 12 genes,
subfamily B contains 7 genes and 2 pseudogenes, and the more
distantly related subfamily C contains 3 genes. The tandem array of
22 large, variable region exons are followed by a constant region,
containing 3 exons shared by all genes in the cluster. Each
variable region exon encodes the extracellular region, which
includes 6 cadherin ectodomains and a transmembrane region. The
constant region exons encode the common cytoplasmic region. These
neural cadherin-like cell adhesion proteins most likely play a
critical role in the establishment and function of specific
cell-cell connections in the brain. Alternative splicing has been
described for the gamma cluster genes.
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Wu, Q., et al. Genome Res. 11(3):389-404(2001)
- Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)
- Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PCDHGA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from the Central region of human PCDHGA1.
NCBI Gene ID #:
56114
NCBI Official Name:
Protocadherin gamma-A1
NCBI Official Symbol:
PCDHGA1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
101 kDa
Protein Accession #:
Q9Y5H4
Protein GI Number:
37999844
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
Q9Y5H4
User NOte:
Optimal dilutions for each application to be determined by the researcher.