COCH Antibody
| Code | Size | Price |
|---|
| PSI-56-727-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Cochlin, COCH-5B2, COCH, COCH5B2
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
The protein encoded by this gene is highly conserved in
human, mouse, and chicken, showing 94% and 79% amino acid identity
of human to mouse and chicken sequences, respectively.
Hybridization to this gene was detected in spindle-shaped cells
located along nerve fibers between the auditory ganglion and
sensory epithelium. These cells accompany neurites at the habenula
perforata, the opening through which neurites extend to innervate
hair cells. This and the pattern of expression of this gene in
chicken inner ear paralleled the histologic findings of acidophilic
deposits, consistent with mucopolysaccharide ground substance, in
temporal bones from DFNA9 (autosomal dominant nonsyndromic
sensorineural deafness 9) patients. Mutations that cause DFNA9 have
been reported in this gene. Alternative splicing results in
multiple transcript variants encoding the same protein. Additional
splice variants encoding distinct isoforms have been described but
their biological validities have not been demonstrated. [provided
by RefSeq].
Background References:
- Ikezono, T., et al. Acta Otolaryngol. 130(8):881-887(2010)
- Yao, J., et al. J. Biol. Chem. 285(20):14909-14919(2010)
- Baek, J.I., et al. Clin. Genet. 77(4):399-403(2010)
- Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This COCH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-428 amino acids from the Central region of human COCH.
NCBI Gene ID #:
1690
NCBI Official Name:
Cochlin
NCBI Official Symbol:
COCH
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
59 kDa
Protein Accession #:
O43405
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
O43405
User NOte:
Optimal dilutions for each application to be determined by the researcher.