AVP Antibody
| Code | Size | Price |
|---|
| PSI-61-973-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Vasopressin-neurophysin 2-copeptin, AVP-NPII, Arg-vasopressin, Arginine-vasopressin, Neurophysin 2, Neurophysin-II, Copeptin, AVP, ARVP, VP
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For IF starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:50~100
For IF starting dilution is: 1:10~50
Background:
This gene encodes a precursor protein consisting of
arginine vasopressin and two associated proteins, neurophysin 2 and
a glycopeptide, copeptin. Arginine vasopressin is a posterior
pituitary hormone which is synthesized in the supraoptic nucleus
and paraventricular nucleus of the hypothalamus. Along with its
carrier protein, neurophysin 2, it is packaged into neurosecretory
vesicles and transported axonally to the nerve endings in the
neurohypophysis where it is either stored or secreted into the
bloodstream. The precursor is thought to be activated while it is
being transported along the axon to the posterior pituitary.
Arginine vasopressin acts as a growth factor by enhancing pH
regulation through acid-base transport systems. It has a direct
antidiuretic action on the kidney, and also causes vasoconstriction
of the peripheral vessels. This hormone can contract smooth muscle
during parturition and lactation. It is also involved in cognition,
tolerance, adaptation and complex sexual and maternal behaviour, as
well as in the regulation of water excretion and cardiovascular
functions.
Background References:
- Abu Libdeh, A., et al. Eur. J. Endocrinol. 162(2):221-226(2010)
- Cirillo, M. Kidney Int. 77(1):5-6(2010)
- Meijer, E., et al. Kidney Int. 77(1):29-36(2010)
- Birk, J., et al. J. Cell. Sci. 122 (PT 21), 3994-4002 (2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This AVP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-129 amino acids from the Central region of human AVP.
NCBI Gene ID #:
551
NCBI Official Name:
Vasopressin-neurophysin 2-copeptin
NCBI Official Symbol:
AVP
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
17 kDa
Protein Accession #:
P01185
Protein GI Number:
128083
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P01185
User NOte:
Optimal dilutions for each application to be determined by the researcher.