HDAC4 Antibody
| Code | Size | Price |
|---|
| PSI-57-218-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Histone deacetylase 4, HD4, HDAC4, KIAA0288
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
Background:
Histones play a critical role in transcriptional
regulation, cell cycle progression, and developmental events.
Histone acetylation/deacetylation alters chromosome structure and
affects transcription factor access to DNA. The protein encoded by
this gene belongs to class II of the histone deacetylase/acuc/apha
family. It possesses histone deacetylase activity and represses
transcription when tethered to a promoter. This protein does not
bind DNA directly, but through transcription factors MEF2C and
MEF2D. It seems to interact in a multiprotein complex with RbAp48
and HDAC3.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Williams, S.R., et al. Am. J. Hum. Genet. 87(2):219-228(2010)
- Kim, T., et al. Psychiatry Res 178(2):266-269(2010)
- Pan, L., et al. Cell. Mol. Immunol. 7(3):221-226(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HDAC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1049-1077 amino acids from the C-terminal region of human HDAC4.
NCBI Gene ID #:
9759
NCBI Official Name:
Histone deacetylase 4
NCBI Official Symbol:
HDAC4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
119 kDa
Protein Accession #:
P56524
Protein GI Number:
259016348
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P56524
User NOte:
Optimal dilutions for each application to be determined by the researcher.