ARRB1 Antibody
| Code | Size | Price |
|---|
| PSI-56-170-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Beta-arrestin-1, Arrestin beta-1, ARRB1, ARR1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
Members of arrestin/beta-arrestin protein family are
thought to participate in agonist-mediated desensitization of
G-protein-coupled receptors and cause specific dampening of
cellular responses to stimuli such as hormones, neurotransmitters,
or sensory signals. Arrestin beta 1 is a cytosolic protein and
acts as a cofactor in the beta-adrenergic receptor kinase (BARK)
mediated desensitization of beta-adrenergic receptors. Besides the
central nervous system, it is expressed at high levels in
peripheral blood leukocytes, and thus the BARK/beta-arrestin system
is believed to play a major role in regulating receptor-mediated
immune functions. Alternatively spliced transcripts encoding
different isoforms of arrestin beta 1 have been described, however,
their exact functions are not known.
Background References:
- Shukla, A.K., et al. J. Biol. Chem. 285(39):30115-30125(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Lee, D.K., et al. Biochem. Biophys. Res. Commun. 395(2):185-189(2010)
- Kim, J.I., et al. Mol. Cancer Res. 8(4):569-577(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rabbit, Rat
Immunogen:
This ARRB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-363 amino acids from the C-terminal region of human ARRB1.
NCBI Gene ID #:
408
NCBI Official Name:
Beta-arrestin-1
NCBI Official Symbol:
ARRB1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
47 kDa
Protein Accession #:
P49407
Protein GI Number:
20141238
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction
Swissprot #:
P49407
User NOte:
Optimal dilutions for each application to be determined by the researcher.