ADRA1B Antibody
Code | Size | Price |
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PSI-60-786-400ul | 400ul | £626.00 |
Quantity:
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Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
Alpha-1B adrenergic receptor, Alpha-1B adrenoreceptor, Alpha-1B adrenoceptor, ADRA1B
Application Note:
For WB starting dilution is: 1:1000
Background:
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of
the G protein-coupled receptor superfamily. They activate mitogenic
responses and regulate growth and proliferation of many cells.
There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of
which signal through the Gq/11 family of G-proteins and different
subtypes show different patterns of activation. This gene encodes
alpha-1B-adrenergic receptor, which induces neoplastic
transformation when transfected into NIH 3T3 fibroblasts and other
cell lines. Thus, this normal cellular gene is identified as a
protooncogene. This gene comprises 2 exons and a single large
intron of at least 20 kb that interrupts the coding region.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Pinheiro, A.P., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Jensen, B.C., et al. Circ Heart Fail 2(6):654-663(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This ADRA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-409 amino acids from the C-terminal region of human ADRA1B.
NCBI Gene ID #:
147
NCBI Official Name:
Alpha-1B adrenergic receptor
NCBI Official Symbol:
ADRA1B
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
57 kDa
Protein Accession #:
P35368
Protein GI Number:
116241241
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction,Growth Factor
Swissprot #:
P35368
User NOte:
Optimal dilutions for each application to be determined by the researcher.