MRGPRX2 Antibody
| Code | Size | Price |
|---|
| PSI-58-544-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Mas-related G-protein coupled receptor member X2, MRGPRX2, MRGX2
Application Note:
For WB starting dilution is: 1:1000
Background:
MRGPRX2 is the orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
Background References:
- Gembardt, F., et al. Mol. Cell. Biochem. 319 (1-2), 115-123 (2008) :
- Yang, S., et al. Gene 352, 30-35 (2005) :
- Robas, N., et al. J. Biol. Chem. 278(45):44400-44404(2003)
- Takeda, S., et al. FEBS Lett. 520 (1-3), 97-101 (2002) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This MRGPRX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from the C-terminal region of human MRGPRX2.
NCBI Gene ID #:
117194
NCBI Official Name:
Mas-related G-protein coupled receptor member X2
NCBI Official Symbol:
MRGPRX2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
37 kDa
Protein Accession #:
Q96LB1
Protein GI Number:
50401127
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction,Growth Factor
Swissprot #:
Q96LB1
User NOte:
Optimal dilutions for each application to be determined by the researcher.