ADRA2C Antibody
| Code | Size | Price |
|---|
| PSI-57-834-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Alpha-2C adrenergic receptor, Alpha-2 adrenergic receptor subtype C4, Alpha-2C adrenoreceptor, Alpha-2C adrenoceptor, Alpha-2CAR, ADRA2C, ADRA2L2, ADRA2RL2
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
Alpha-2-adrenergic receptors are members of the G
protein-coupled receptor superfamily. They include 3 highly
homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors
have a critical role in regulating neurotransmitter release from
sympathetic nerves and from adrenergic neurons in the central
nervous system. The mouse studies revealed that both the alpha2A
and alpha2C subtypes were required for normal presynaptic control
of transmitter release from sympathetic nerves in the heart and
from central noradrenergic neurons. The alpha2A subtype inhibited
transmitter release at high stimulation frequencies, whereas the
alpha2C subtype modulated neurotransmission at lower levels of
nerve activity. This gene encodes the alpha2C subtype, which
contains no introns in either its coding or untranslated sequences.
Background References:
- Chen, Q.J., et al. Clin. Biochem. 43(15):1201-1204(2010)
- Maqbool, A., et al. J. Hypertens. 28(10):2084-2093(2010)
- Saus, E., et al.Psychiatr Res 44(14):971-978(2010)
- Gao, Y., et al. Ophthalmology (2010) In press :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This ADRA2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-382 amino acids from the C-terminal region of human ADRA2C.
NCBI Gene ID #:
152
NCBI Official Name:
Alpha-2C adrenergic receptor
NCBI Official Symbol:
ADRA2C
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
P18825
Protein GI Number:
20141211
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Neuroscience,Signal Transduction,Growth Factor
Swissprot #:
P18825
User NOte:
Optimal dilutions for each application to be determined by the researcher.