PPARD Antibody
| Code | Size | Price |
|---|
| PSI-57-265-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Peroxisome proliferator-activated receptor delta, PPAR-delta, NUCI, Nuclear hormone receptor 1, NUC1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferator-activated receptor beta, PPAR-beta, PPARD, NR1C2, PPARB
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the peroxisome
proliferator-activated receptor (PPAR) family. PPARs are nuclear
hormone receptors that bind peroxisome proliferators and control
the size and number of peroxisomes produced by cells. PPARs mediate
a variety of biological processes, and may be involved in the
development of several chronic diseases, including diabetes,
obesity, atherosclerosis, and cancer. This protein is a potent
inhibitor of ligand-induced transcription activity of PPAR alpha
and PPAR gamma. It may function as an integrator of transcription
repression and nuclear receptor signaling. The expression of this
gene is found to be elevated in colorectal cancer cells. The
elevated expression can be repressed by adenomatosis polyposis coli
(APC), a tumor suppressor protein related to APC/beta-catenin
signaling pathway. Knockout studies in mice suggested the role of
this protein in myelination of the corpus callosum, lipid
metabolism, and epidermal cell proliferation. Alternate splicing
results in multiple transcript variants.
Background References:
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Christopoulos, P., et al. Ann. N. Y. Acad. Sci. 1205, 185-191 (2010) :
- Dunn, S.E., et al. J. Exp. Med. 207(8):1599-1608(2010)
- Eynon, N., et al. Mitochondrion (2010) In press :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PPARD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 364-393 amino acids from the C-terminal region of human PPARD.
NCBI Gene ID #:
5467
NCBI Official Name:
Peroxisome proliferator-activated receptor delta
NCBI Official Symbol:
PPARD
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
50 kDa
Protein Accession #:
Q03181
Protein GI Number:
417522
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity
Swissprot #:
Q03181
User NOte:
Optimal dilutions for each application to be determined by the researcher.