EIF2AK3 Antibody
| Code | Size | Price |
|---|
| PSI-57-811-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Eukaryotic translation initiation factor 2-alpha kinase 3, PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, HsPEK, EIF2AK3, PEK, PERK
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
The protein encoded by this gene phosphorylates the alpha
subunit of eukaryotic translation-initiation factor 2 (EIF2),
leading to its inactivation, and thus to a rapid reduction of
translational initiation and repression of global protein
synthesis. It is a type I membrane protein located in the
endoplasmic reticulum (ER), where it is induced by ER stress caused
by malfolded proteins. Mutations in this gene are associated with
Wolcott-Rallison syndrome.
Background References:
- Xu, H., et al. Toxicology 277 (1-3), 1-5 (2010) :
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Kim, K.W., et al. Oncogene 29(22):3241-3251(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This EIF2AK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-102 amino acids from the N-terminal region of human EIF2AK3.
NCBI Gene ID #:
9451
NCBI Official Name:
Eukaryotic translation initiation factor 2-alpha kinase 3
NCBI Official Symbol:
EIF2AK3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
125 kDa
Protein Accession #:
Q9NZJ5
Protein GI Number:
296439367
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity
Swissprot #:
Q9NZJ5
User NOte:
Optimal dilutions for each application to be determined by the researcher.