CLCN3 Antibody
| Code | Size | Price |
|---|
| PSI-58-987-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
H(+)/Cl(-) exchange transporter 3, Chloride channel protein 3, ClC-3, Chloride transporter ClC-3, CLCN3
Application Note:
For WB starting dilution is: 1:1000
Background:
CLCN3 mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
Background References:
- Cuddapah, V.A., et al. J. Biol. Chem. 285(15):11188-11196(2010)
- Xiong, D., et al. Clin. Exp. Pharmacol. Physiol. 36(4):386-393(2009)
- Yin, Z., et al. Am. J. Physiol., Cell Physiol. 294 (2), C535-C542 (2008) :
- Matsuda, J.J., et al. Am. J. Physiol., Cell Physiol. 294 (1), C251-C262 (2008) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rabbit, Rat
Immunogen:
This CLCN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-313 amino acids from the Central region of human CLCN3.
NCBI Gene ID #:
1182
NCBI Official Name:
H(+)/Cl(-) exchange transporter 3
NCBI Official Symbol:
CLCN3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
91 kDa
Protein Accession #:
P51790
Protein GI Number:
226693513
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Neuroscience,Signal Transduction
Swissprot #:
P51790
User NOte:
Optimal dilutions for each application to be determined by the researcher.