NPC1L1 Antibody
| Code | Size | Price |
|---|
| PSI-60-959-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Niemann-Pick C1-like protein 1, NPC1L1
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a multi-pass membrane
protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1)
domain and a putative sterol-sensing domain (SSD) which includes a
YQRL motif functioning as a plasma membrane to trans-Golgi network
transport signal in other proteins. This protein takes up free
cholesterol into cells through vesicular endocytosis and plays a
critical role in the absorption of intestinal cholesterol. It also
has the ability to transport alpha-tocopherol (vitamin E). The drug
ezetimibe targets this protein and inhibits the absorption of
intestinal cholesterol and alpha-tocopherol. In addition, this
protein may play a critical role in regulating lipid metabolism.
Polymorphic variations in this gene are associated with plasma
total cholesterol and low-density lipoprotein cholesterol (LDL-C)
levels and coronary heart disease (CHD) risk. Alternatively spliced
transcript variants encoding different isoforms have been found for
this gene.
Background References:
- Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Teslovich, T.M., et al. Nature 466(7307):707-713(2010)
- Pramfalk, C., et al. J. Lipid Res. 51(6):1354-1362(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This NPC1L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-323 amino acids from the N-terminal region of human NPC1L1.
NCBI Gene ID #:
29881
NCBI Official Name:
Niemann-Pick C1-like protein 1
NCBI Official Symbol:
NPC1L1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
149 kDa
Protein Accession #:
Q9UHC9
Protein GI Number:
425906049
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Neuroscience,Signal Transduction
Swissprot #:
Q9UHC9
User NOte:
Optimal dilutions for each application to be determined by the researcher.