DMGDH Antibody
| Code | Size | Price |
|---|
| PSI-59-586-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Dimethylglycine dehydrogenase, mitochondrial, ME2GLYDH, DMGDH
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes an enzyme involved in the catabolism of
choline, catalyzing the oxidative demethylation of dimethylglycine
to form sarcosine. The enzyme is found as a monomer in the
mitochondrial matrix, and uses flavin adenine dinucleotide and
folate as cofactors. Mutation in this gene causes dimethylglycine
dehydrogenase deficiency, characterized by a fishlike body odor,
chronic muscle fatigue, and elevated levels of the muscle form of
creatine kinase in serum.
Background References:
- Mostowska, A., et al. Eur. J. Oral Sci. 118(4):325-332(2010)
- Bailey, S.D., et al. Diabetes Care (2010) In press :
- Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This DMGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 836-864 amino acids from the C-terminal region of human DMGDH.
NCBI Gene ID #:
29958
NCBI Official Name:
Dimethylglycine dehydrogenase, mitochondrial
NCBI Official Symbol:
DMGDH
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
97 kDa
Protein Accession #:
Q9UI17
Protein GI Number:
296434575
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Neuroscience,Signal Transduction
Swissprot #:
Q9UI17
User NOte:
Optimal dilutions for each application to be determined by the researcher.