PADI2 Antibody
| Code | Size | Price |
|---|
| PSI-57-682-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Protein-arginine deiminase type-2, PAD-H19, Peptidylarginine deiminase II, Protein-arginine deiminase type II, PADI2, KIAA0994, PDI2
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the peptidyl arginine
deiminase family of enzymes, which catalyze the post-translational
deimination of proteins by converting arginine residues into
citrullines in the presence of calcium ions. The family members
have distinct substrate specificities and tissue-specific
expression patterns. The type II enzyme is the most widely
expressed family member. Known substrates for this enzyme include
myelin basic protein in the central nervous system and vimentin in
skeletal muscle and macrophages. This enzyme is thought to play a
role in the onset and progression of neurodegenerative human
disorders, including Alzheimer disease and multiple sclerosis, and
it has also been implicated in glaucoma pathogenesis. This gene
exists in a cluster with four other paralogous genes. [provided by
RefSeq].
Background References:
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Jang, B., et al. Acta Neuropathol. 119(2):199-210(2010)
- Cafaro, T.A., et al. Mol. Vis. 16, 1654-1658 (2010) :
- Hojo-Nakashima, I., et al. J. Biochem. 146(4):471-479(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PADI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 557-586 amino acids from the C-terminal region of human PADI2.
NCBI Gene ID #:
11240
NCBI Official Name:
Protein-arginine deiminase type-2
NCBI Official Symbol:
PADI2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
76 kDa
Protein Accession #:
Q9Y2J8
Protein GI Number:
7531171
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Neuroscience,Signal Transduction
Swissprot #:
Q9Y2J8
User NOte:
Optimal dilutions for each application to be determined by the researcher.