PTPRN Antibody
| Code | Size | Price |
|---|
| PSI-57-787-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP possesses an extracellular
region, a single transmembrane region, and a single catalytic
domain, and thus represents a receptor-type PTP. This PTP was found
to be an autoantigen that is reactive with insulin-dependent
diabetes mellitus (IDDM) patient sera, and thus may be a potential
target of autoimmunity in diabetes mellitus.
Background References:
- Yu, L., et al. J. Immunol. Methods 353 (1-2), 20-23 (2010) :
- Honeyman, M.C., et al. J. Immunol. 184(4):2204-2210(2010)
- Weenink, S.M., et al. J. Autoimmun. 33(2):147-154(2009)
- Burbelo, P.D., et al. Diabetes Care 31(9):1824-1826(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This PTPRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-316 amino acids from the Central region of human PTPRN.
NCBI Gene ID #:
5798
NCBI Official Name:
Receptor-type tyrosine-protein phosphatase-like N
NCBI Official Symbol:
PTPRN
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
106 kDa
Protein Accession #:
Q16849
Protein GI Number:
2499754
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Neuroscience,Signal Transduction
Swissprot #:
Q16849
User NOte:
Optimal dilutions for each application to be determined by the researcher.