QPRT Antibody
| Code | Size | Price |
|---|
| PSI-57-694-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Nicotinate-nucleotide pyrophosphorylase [carboxylating], Quinolinate phosphoribosyltransferase [decarboxylating], QAPRTase, QPRTase, QPRT
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a key enzyme in catabolism of
quinolinate, an intermediate in the tryptophan-nicotinamide adenine
dinucleotide pathway. Quinolinate acts as a most potent endogenous
exitotoxin to neurons. Elevation of quinolinate levels in the brain
has been linked to the pathogenesis of neurodegenerative disorders
such as epilepsy, Alzheimer's disease, and Huntington's disease.
Background References:
- Hinsch, N., et al. BMC Cancer 9, 93 (2009) :
- Liu, H., et al. J. Mol. Biol. 373(3):755-763(2007)
- Magni, G., et al. Cell. Mol. Life Sci. 61(1):19-34(2004)
- Fukuoka, S., et al. Adv. Exp. Med. Biol. 467, 611-614 (1999) :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This QPRT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-234 amino acids from the C-terminal region of human QPRT.
NCBI Gene ID #:
23475
NCBI Official Name:
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
NCBI Official Symbol:
QPRT
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
31 kDa
Protein Accession #:
Q15274
Protein GI Number:
296439291
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Neuroscience,Signal Transduction
Swissprot #:
Q15274
User NOte:
Optimal dilutions for each application to be determined by the researcher.