CLOCK Antibody
| Code | Size | Price |
|---|
| PSI-63-013-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Circadian locomoter output cycles protein kaput, hCLOCK, Class E basic helix-loop-helix protein 8, bHLHe8, CLOCK, BHLHE8, KIAA0334
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
CLOCK belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within this protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.
Background References:
- Sookoian,S., Am. J. Clin. Nutr. 87 (6), 1606-1615 (2008)
- Nakashima,A., Mol. Cell. Biol. 28 (12), 4080-4092 (2008)
- Marino,J.L., Epidemiology 19 (3), 477-484 (2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This CLOCK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-249 amino acids from the Central region of human CLOCK.
NCBI Gene ID #:
9575
NCBI Official Name:
Circadian locomoter output cycles protein kaput
NCBI Official Symbol:
CLOCK
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
95 kDa
Protein Accession #:
O15516
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Obesity,Neuroscience,Signal Transduction
Swissprot #:
O15516
User NOte:
Optimal dilutions for each application to be determined by the researcher.