CLC4 Antibody

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ProSci
Product Code: PSI-62-251
Product Group: Primary Antibodies
Supplier: ProSci
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PSI-62-251-400ul400ul£626.00
Quantity:
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Overview

Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
  • Immunofluorescence (IF)
  • Immunohistochemistry- Paraffin Embedded (IHC-P)
  • Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Images

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Western blot of chicken brain tissue incubated with CLC4 Antibody . Data courtesy of Emily McMains, Louisiana State University.
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Immunofluorescence image of cultured chick retinal amacrine (neuronal) cells labeled with CLC4 Antibody . Data courtesy of Emily McMains, Louisiana State University.
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Western blot of chicken brain tissue incubated with CLC4 Antibody . Data courtesy of Emily McMains, Louisiana State University.
Immunofluorescence image of cultured chick retinal amacrine (neuronal) cells labeled with CLC4 Antibody . Data courtesy of Emily McMains, Louisiana State University.

Documents

Further Information

Additional Names:
H(+)/Cl(-) exchange transporter 4, Chloride channel protein 4, ClC-4, Chloride transporter ClC-4, CLCN4
Application Note:
For WB starting dilution is: 1:1000

For IF starting dilution is: 1:10~50

For IHC-P starting dilution is: 1:10~50
Background:
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders.
Background References:
  • Wang, T., et al., Gastroenterology 126(4):1157-1166 (2004).
  • Lamb, F.S., et al., J. Mol. Cell. Cardiol. 31(3):657-666 (1999).
  • Dinulos, M.B., et al., Genomics 35(1):244-247 (1996).
  • Schnur, R.E., et al., Hum. Genet. 95(5):594-595 (1995).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Immunogen:
This CLC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-689 amino acids from the C-terminal region of human CLC4.
NCBI Gene ID #:
1183
NCBI Official Name:
H(+)/Cl(-) exchange transporter 4
NCBI Official Symbol:
CLCN4
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
85 kDa
Protein Accession #:
P51793
Protein GI Number:
20141247
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Research Area:
Obesity,Neuroscience,Signal Transduction
Swissprot #:
P51793
User NOte:
Optimal dilutions for each application to be determined by the researcher.