HTR2C Antibody
| Code | Size | Price |
|---|
| PSI-57-337-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
5-hydroxytryptamine receptor 2C, 5-HT-2C, 5-HT2C, 5-HTR2C, 5-hydroxytryptamine receptor 1C, 5-HT-1C, 5-HT1C, Serotonin receptor 2C, HTR2C, HTR1C
Application Note:
For WB starting dilution is: 1:1000
Background:
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter,
elicits a wide array of physiological effects by binding to several
receptor subtypes, including the 5-HT2 family of
seven-transmembrane-spanning, G-protein-coupled receptors, which
activate phospholipase C and D signaling pathways. This gene
encodes the 2C subtype of serotonin receptor and its mRNA is
subject to multiple RNA editing events, where genomically encoded
adenosine residues are converted to inosines. RNA editing is
predicted to alter amino acids within the second intracellular loop
of the 5-HT2C receptor and generate receptor isoforms that differ
in their ability to interact with G proteins and the activation of
phospholipase C and D signaling cascades, thus modulating
serotonergic neurotransmission in the central nervous system.
Studies in humans have reported abnormalities in patterns of 5-HT2C
editing in depressed suicide victims.
Background References:
- Gregoor, J.G., et al. Psychiatr. Genet. 20(6):311-316(2010)
- Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- Kiezebrink, K., et al. World J. Biol. Psychiatry 11(6):824-833(2010)
- Risselada, A.J., et al. Pharmacogenomics J. (2010) In press :
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This HTR2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the Central region of human HTR2C.
NCBI Gene ID #:
3358
NCBI Official Name:
5-hydroxytryptamine receptor 2C
NCBI Official Symbol:
HTR2C
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
52 kDa
Protein Accession #:
P28335
Protein GI Number:
112816
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Neuroscience,Signal Transduction,Growth Factor
Swissprot #:
P28335
User NOte:
Optimal dilutions for each application to be determined by the researcher.