CDS2 Antibody
| Code | Size | Price |
|---|
| PSI-58-974-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Phosphatidate cytidylyltransferase 2, CDP-DAG synthase 2, CDP-DG synthase 2, CDP-diacylglycerol synthase 2, CDS 2, CDP-diglyceride pyrophosphorylase 2, CDP-diglyceride synthase 2, CTP:phosphatidate cytidylyltransferase 2, CDS2
Application Note:
For WB starting dilution is: 1:1000
Background:
Breakdown products of phosphoinositides are ubiquitous
second messengers that function downstream of many G
protein-coupled receptors and tyrosine kinases regulating cell
growth, calcium metabolism, and protein kinase C activity. This
gene encodes an enzyme which regulates the amount of
phosphatidylinositol available for signaling by catalyzing the
conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme
is an integral membrane protein localized to two subcellular
domains, the matrix side of the inner mitochondrial membrane where
it is thought to be involved in the synthesis of
phosphatidylglycerol and cardiolipin and the cytoplasmic side of
the endoplasmic reticulum where it functions in
phosphatidylinositol biosynthesis. Two genes encoding this enzyme
have been identified in humans, one mapping to human chromosome
4q21 and a second to 20p13.
Background References:
- Bailey, S.D., et al. Diabetes Care (2010) In press :
- Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- Olsen, J.V., et al. Cell 127(3):635-648(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Immunogen:
This CDS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-165 amino acids from the Central region of human CDS2.
NCBI Gene ID #:
8760
NCBI Official Name:
Phosphatidate cytidylyltransferase 2
NCBI Official Symbol:
CDS2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
51 kDa
Protein Accession #:
O95674
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
O95674
User NOte:
Optimal dilutions for each application to be determined by the researcher.