NR1I3 Antibody
| Code | Size | Price |
|---|
| PSI-57-837-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Nuclear receptor subfamily 1 group I member 3, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, NR1I3, CAR
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene encodes a member of the nuclear receptor
superfamily, and is a key regulator of xenobiotic and endobiotic
metabolism. The protein binds to DNA as a monomer or a heterodimer
with the retinoid X receptor and regulates the transcription of
target genes involved in drug metabolism and bilirubin clearance,
such as cytochrome P450 family members. Unlike most nuclear
receptors, this transcriptional regulator is constitutively active
in the absence of ligand but is regulated by both agonists and
inverse agonists. Ligand binding results in translocation of this
protein to the nucleus, where it activates or represses target gene
transcription. These ligands include bilirubin, a variety of
foreign compounds, steroid hormones, and prescription drugs.
Multiple transcript variants encoding different isoforms have been
found for this gene.
Background References:
- Benet, M., et al. J. Biol. Chem. 285(37):28457-28471(2010)
- Oliver, P., et al. Clin. Chem. Lab. Med. 48(5):635-639(2010)
- Masuyama, H., et al. Mol. Endocrinol. 24(4):745-753(2010)
- Mutoh, S., et al. J. Biol. Chem. 284(50):34785-34792(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This NR1I3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-183 amino acids from the Central region of human NR1I3.
NCBI Gene ID #:
9970
NCBI Official Name:
Nuclear receptor subfamily 1 group I member 3
NCBI Official Symbol:
NR1I3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
40 kDa
Protein Accession #:
Q14994
Protein GI Number:
49066046
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
Q14994
User NOte:
Optimal dilutions for each application to be determined by the researcher.