NEU1 Antibody
| Code | Size | Price |
|---|
| PSI-60-825-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Sialidase-1, Acetylneuraminyl hydrolase, G9 sialidase, Lysosomal sialidase, N-acetyl-alpha-neuraminidase 1, NEU1, NANH
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene is a lysosomal enzyme
that cleaves terminal sialic acid residues from substrates such as
glycoproteins and glycolipids. In the lysosome, this enzyme is part
of a heterotrimeric complex together with beta-galactosidase and
cathepsin A (the latter is also referred to as 'protective
protein'). Mutations in this gene can lead to sialidosis, a
lysosomal storage disease that can be type 1 (cherry red
spot-myoclonus syndrome or normosomatic type), which is late-onset,
or type 2 (the dysmorphic type), which occurs at an earlier age
with increased severity.
Background References:
- Caciotti, A., et al. J. Neurol. 256(11):1911-1915(2009)
- Bonten, E.J., et al. J. Biol. Chem. 284(41):28430-28441(2009)
- Barcellos, L.F., et al. PLoS Genet.(10), E1000696 (2009) :
- Wang, J., et al. J. Neurochem. 111(2):547-554(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This NEU1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-214 amino acids from the Central region of human NEU1.
NCBI Gene ID #:
4758
NCBI Official Name:
Sialidase-1
NCBI Official Symbol:
NEU1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
45 kDa
Protein Accession #:
Q99519
Protein GI Number:
17368612
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
Q99519
User NOte:
Optimal dilutions for each application to be determined by the researcher.