PLN Antibody
| Code | Size | Price |
|---|
| PSI-61-011-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Cardiac phospholamban, PLB, PLN, PLB
Application Note:
For WB starting dilution is: 1:1000
Background:
Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2 Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
Background References:
- Fujii J.,et al.J. Biol. Chem. 266:11669-11675(1991).
- Salvatore C.A.,et al.Submitted (MAR-1991) to the EMBL/GenBank/DDBJ databases.
- McTiernan C.F.,et al.J. Mol. Cell. Cardiol. 31:679-692(1999).
- Minamisawa S.,et al.Biochem. Biophys. Res. Commun. 304:1-4(2003).
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig, Rabbit, Rat
Immunogen:
This PLN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-22 amino acids from the N-terminal region of human PLN.
NCBI Gene ID #:
5350
NCBI Official Name:
Cardiac phospholamban
NCBI Official Symbol:
PLN
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
6 kDa
Protein Accession #:
P26678
Protein GI Number:
130774
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
P26678
User NOte:
Optimal dilutions for each application to be determined by the researcher.