CTPS2 Antibody
| Code | Size | Price |
|---|
| PSI-56-805-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
CTP synthase 2, CTP synthetase 2, UTP--ammonia ligase 2, CTPS2
Application Note:
For WB starting dilution is: 1:1000
Background:
The protein encoded by this gene catalyzes the formation
of CTP from UTP with the concomitant deamination of glutamine to
glutamate. This protein is the rate-limiting enzyme in the
synthesis of cytosine nucleotides, which play an important role in
various metabolic processes and provide the precursors necessary
for the synthesis of RNA and DNA. Cancer cells that exhibit
increased cell proliferation also exhibit an increased activity of
this encoded protein. Thus, this protein is an attractive target
for selective chemotherapy. Three alternatively spliced transcript
variants encoding the same protein have been described for this
gene.
Background References:
- Kassel, K.M., et al. J. Biol. Chem. 285(44):33727-33736(2010)
- Olsen, J.V., et al. Cell 127(3):635-648(2006)
- Han, G.S., et al. J. Biol. Chem. 280(46):38328-38336(2005)
- Ross, M.T., et al. Nature 434(7031):325-337(2005)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This CTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 450-479 amino acids from the C-terminal region of human CTPS2.
NCBI Gene ID #:
56474
NCBI Official Name:
CTP synthase 2
NCBI Official Symbol:
CTPS2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
66 kDa
Protein Accession #:
Q9NRF8
Protein GI Number:
74752919
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
Q9NRF8
User NOte:
Optimal dilutions for each application to be determined by the researcher.