BEST3 Antibody
| Code | Size | Price |
|---|
| PSI-60-376-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Bestrophin-3, Vitelliform macular dystrophy 2-like protein 3, BEST3, VMD2L3
Application Note:
For WB starting dilution is: 1:1000
Background:
BEST3 belongs to the bestrophin family of anion channels,
which includes BEST1 (MIM 607854), the gene mutant in vitelliform
macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes,
BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are
transmembrane (TM) proteins that share a homology region containing
a high content of aromatic residues, including an invariant
arg-phe-pro (RFP) motif. The bestrophin genes share a conserved
gene structure, with almost identical sizes of the 8 RFP-TM
domain-encoding exons and highly conserved exon-intron boundaries.
Each of the 4 bestrophin genes has a unique 3-prime end of variable
length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al.,
2003 [PubMed 12907679]).
Background References:
- Marsey, L.L., et al. J. Physiol. (Lond.) 587 (PT 10), 2211-2224 (2009) :
- Qu, Z.Q., et al. J. Biol. Chem. 282(24):17460-17467(2007)
- Tsunenari, T., et al. J. Biol. Chem. 278(42):41114-41125(2003)
- Stohr, H., et al. Eur. J. Hum. Genet. 10(4):281-284(2002)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This BEST3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-68 amino acids from the N-terminal region of human BEST3.
NCBI Gene ID #:
144453
NCBI Official Name:
Bestrophin-3
NCBI Official Symbol:
BEST3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
76 kDa
Protein Accession #:
Q8N1M1
Protein GI Number:
38503351
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
Q8N1M1
User NOte:
Optimal dilutions for each application to be determined by the researcher.