FMO5 Antibody
| Code | Size | Price |
|---|
| PSI-60-965-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Dimethylaniline monooxygenase [N-oxide-forming] 5, Dimethylaniline oxidase 5, Hepatic flavin-containing monooxygenase 5, FMO 5, FMO5
Application Note:
For WB starting dilution is: 1:1000
Background:
Metabolic N-oxidation of the diet-derived
amino-trimethylamine (TMA) is mediated by flavin-containing
monooxygenase and is subject to an inherited FMO3 polymorphism in
man resulting in a small subpopulation with reduced TMA N-oxidation
capacity resulting in fish odor syndrome Trimethylaminuria. Three
forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult
liver, and FMO3 are encoded by genes clustered in the 1q23-q25
region. Flavin-containing monooxygenases are NADPH-dependent
flavoenzymes that catalyzes the oxidation of soft nucleophilic
heteroatom centers in drugs, pesticides, and xenobiotics.
Alternative splicing results in multiple transcript variants.
Background References:
- Rose, J. Phd, et al. Mol. Med. (2010) In press :
- Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)
- Wheeler, H.E., et al. PLoS Genet.(10), E1000685 (2009) :
- Zhang, J., et al. Drug Metab. Dispos. 34(1):19-26(2006)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This FMO5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-502 amino acids from the C-terminal region of human FMO5.
NCBI Gene ID #:
2330
NCBI Official Name:
Dimethylaniline monooxygenase [N-oxide-forming] 5
NCBI Official Symbol:
FMO5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
60 kDa
Protein Accession #:
P49326
Protein GI Number:
1346021
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
P49326
User NOte:
Optimal dilutions for each application to be determined by the researcher.