SORD Antibody
| Code | Size | Price |
|---|
| PSI-58-227-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Sorbitol dehydrogenase, L-iditol 2-dehydrogenase, SORD
Application Note:
For WB starting dilution is: 1:1000
Background:
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the
interconversion of polyols and their corresponding ketoses, and
together with aldose reductase (ALDR1; MIM 103880), makes up the
sorbitol pathway that is believed to play an important role in the
development of diabetic complications (summarized by Carr and
Markham, 1995 [PubMed 8535074]). The first reaction of the pathway
(also called the polyol pathway) is the reduction of glucose to
sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes
the sorbitol to fructose using NAD(+) cofactor.
Background References:
- Szabo, Z., et al. Oncol. Rep. 23(5):1233-1239(2010)
- Johnatty, S.E., et al. PLoS Genet.(7), E1001016 (2010) :
- El-Kabbani, O., et al. Curr. Med. Chem. 11(4):465-476(2004)
- Pauly, T.A., et al. Structure 11(9):1071-1085(2003)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This SORD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-239 amino acids from the Central region of human SORD.
NCBI Gene ID #:
6652
NCBI Official Name:
Sorbitol dehydrogenase
NCBI Official Symbol:
SORD
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
38 kDa
Protein Accession #:
Q00796
Protein GI Number:
292495088
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
Q00796
User NOte:
Optimal dilutions for each application to be determined by the researcher.