METAP2 Antibody
| Code | Size | Price |
|---|
| PSI-57-699-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, MetAP 2 {ECO:0000255|HAMAP-Rule:MF_03175}, 341118 {ECO:0000255|HAMAP-Rule:MF_03175}, Initiation factor 2-associated 67 kDa glycoprotein {ECO:0000255|HAMAP-Rule:MF_03175}, p67 {ECO:0000255|HAMAP-Rule:MF_03175}, p67eIF2 {ECO:0000255|HAMAP-Rule:MF_03175}, Peptidase M {ECO:0000255|HAMAP-Rule:MF_03175}, METAP2 {ECO:0000255|HAMAP-Rule:MF_03175}
Application Note:
For WB starting dilution is: 1:1000
Background:
This gene is a member of the methionyl aminopeptidase
family and encodes a protein that binds 2 cobalt or manganese ions.
This protein functions both by protecting the alpha subunit of
eukaryotic initiation factor 2 from inhibitory phosphorylation and
by removing the amino-terminal methionine residue from nascent
protein. Increased expression of this gene is associated with
various forms of cancer and the anti-cancer drugs fumagillin and
ovalicin inhibit the protein by irreversibly binding to its active
site. A pseudogene of this gene is located on chromosome 2.
Background References:
- Xiao, Q., et al. Biochemistry 49(26):5588-5599(2010)
- Wang, X., et al. PLoS ONE(8), E11934 (2010) :
- Selvakumar, P., et al. Mol. Cancer 8, 65 (2009) :
- Warder, S.E., et al. J. Proteome Res. 7(11):4807-4820(2008)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This METAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human METAP2.
NCBI Gene ID #:
10988
NCBI Official Name:
Methionine aminopeptidase 2 {ECO:0000255|HAMAP-Rule:MF_03175}
NCBI Official Symbol:
METAP2
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
53 kDa
Protein Accession #:
P50579
Protein GI Number:
1703273
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
P50579
User NOte:
Optimal dilutions for each application to be determined by the researcher.