CYP2D6 Antibody
| Code | Size | Price |
|---|
| PSI-57-786-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Cytochrome P450 2D6, CYPIID6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CYP2DL1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes a member of the cytochrome P450
superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug
metabolism and synthesis of cholesterol, steroids and other lipids.
This protein localizes to the endoplasmic reticulum and is known to
metabolize as many as 20% of commonly prescribed drugs. Its
substrates include debrisoquine, an adrenergic-blocking drug;
sparteine and propafenone, both anti-arrythmic drugs; and
amitryptiline, an anti-depressant. The gene is highly polymorphic
in the population; certain alleles result in the poor metabolizer
phenotype, characterized by a decreased ability to metabolize the
enzyme's substrates. The gene is located near two cytochrome P450
pseudogenes on chromosome 22q13.1. Alternatively spliced transcript
variants encoding different isoforms have been found for this gene.
Background References:
- Abduljalil, K., et al. Clin. Pharmacol. Ther. 88(5):643-651(2010)
- Novalbos, J., et al.Clin Psychopharmacol 30(5):504-511(2010)
- Thompson, A.M., et al. Breast Cancer Res. Treat. (2010) In press :
- Gonzalez-Tejera, G., et al.R Health Sci29(3):299-304(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This CYP2D6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the N-terminal region of human CYP2D6.
NCBI Gene ID #:
1565
NCBI Official Name:
Cytochrome P450 2D6
NCBI Official Symbol:
CYP2D6
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
56 kDa
Protein Accession #:
P10635
Protein GI Number:
84028191
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
P10635
User NOte:
Optimal dilutions for each application to be determined by the researcher.