GBA3 Antibody
| Code | Size | Price |
|---|
| PSI-56-324-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Cytosolic beta-glucosidase, Cytosolic beta-glucosidase-like protein 1, GBA3, CBG, CBGL1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
GBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a
predominantly liver enzyme that efficiently hydrolyzes
beta-D-glucoside and beta-D-galactoside, but not any known
physiologic beta-glycoside, suggesting that it may be involved in
detoxification of plant glycosides (de Graaf et al., 2001 [PubMed
11389701]). GBA3 also has significant neutral glycosylceramidase
activity (EC 3.2.1.62), suggesting that it may be involved in a
nonlysosomal catabolic pathway of glucosylceramide metabolism
(Hayashi et al., 2007 [PubMed 17595169]).
Background References:
- Dekker, N., et al. Blood Cells Mol. Dis. (2010) In press :
- Noguchi, J., et al. Biochem. Biophys. Res. Commun. 374(3):549-552(2008)
- Hayashi, Y., et al. J. Biol. Chem. 282(42):30889-30900(2007)
- Tribolo, S., et al. J. Mol. Biol. 370(5):964-975(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This GBA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the C-terminal region of human GBA3.
NCBI Gene ID #:
57733
NCBI Official Name:
Cytosolic beta-glucosidase
NCBI Official Symbol:
GBA3
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
54 kDa
Protein Accession #:
Q9H227
Protein GI Number:
77416427
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
Q9H227
User NOte:
Optimal dilutions for each application to be determined by the researcher.