SHMT1 Antibody
| Code | Size | Price |
|---|
| PSI-57-723-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Serine hydroxymethyltransferase, cytosolic, SHMT, Glycine hydroxymethyltransferase, Serine methylase, SHMT1
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes the cellular form of serine
hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme
that catalyzes the reversible conversion of serine and
tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate.
This reaction provides one carbon units for synthesis of
methionine, thymidylate, and purines in the cytoplasm. This gene is
located within the Smith-Magenis syndrome region on chromosome 17.
Alternative splicing of this gene results in 2 transcript variants
encoding 2 different isoforms. Additional transcript variants have
been described, but their biological validity has not been
determined.
Background References:
- Porter, K.E., et al. Environ. Res. 110(6):580-587(2010)
- Summers, C.M., et al. Birth Defects Res. PartClin. Mol. Teratol. 88(8):679-688(2010)
- Vijayakrishnan, J., et al. Haematologica 95(8):1405-1414(2010)
- Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1812-1821(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This SHMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 amino acids from the N-terminal region of human SHMT1.
NCBI Gene ID #:
6470
NCBI Official Name:
Serine hydroxymethyltransferase, cytosolic
NCBI Official Symbol:
SHMT1
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
53 kDa
Protein Accession #:
P34896
Protein GI Number:
462184
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
P34896
User NOte:
Optimal dilutions for each application to be determined by the researcher.