OGDH Antibody
| Code | Size | Price |
|---|
| PSI-57-045-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
2-oxoglutarate dehydrogenase, mitochondrial, 2-oxoglutarate dehydrogenase complex component E1, OGDC-E1, Alpha-ketoglutarate dehydrogenase, OGDH
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
Background:
This gene encodes one subunit of the 2-oxoglutarate
dehydrogenase complex. This complex catalyzes the overall
conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA
and CO(2) during the Krebs cycle. The protein is located in the
mitochondrial matrix and uses thiamine pyrophosphate as a cofactor.
A congenital deficiency in 2-oxoglutarate dehydrogenase activity is
believed to lead to hypotonia, metabolic acidosis, and
hyperlactatemia. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.
Background References:
- van Bever, Y., et al. Am. J. Med. Genet.143(7):763-767(2007)
- Shi, Q., et al. J. Biol. Chem. 280(12):10888-10896(2005)
- Habelhah, H., et al. J. Biol. Chem. 279(51):53782-53788(2004)
- McCartney, R.G., et al. J. Biol. Chem. 273(37):24158-24164(1998)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This OGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-410 amino acids from the C-terminal region of human OGDH.
NCBI Gene ID #:
4967
NCBI Official Name:
2-oxoglutarate dehydrogenase, mitochondrial
NCBI Official Symbol:
OGDH
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
116 kDa
Protein Accession #:
Q02218
Protein GI Number:
160332299
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
Q02218
User NOte:
Optimal dilutions for each application to be determined by the researcher.