COX10 Antibody
| Code | Size | Price |
|---|
| PSI-55-363-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
Protoheme IX farnesyltransferase, mitochondrial, 251-, Heme O synthase, COX10
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:50~100
For FACS starting dilution is: 1:10~50
Background:
Cytochrome c oxidase (COX), the terminal component of the
mitochondrial respiratory chain, catalyzes the electron transfer
from reduced cytochrome c to oxygen. This component is a
heteromeric complex consisting of 3 catalytic subunits encoded by
mitochondrial genes and multiple structural subunits encoded by
nuclear genes. The mitochondrially-encoded subunits function in
electron transfer, and the nuclear-encoded subunits may function in
the regulation and assembly of the complex. This nuclear gene
encodes heme A:farnesyltransferase, which is not a structural
subunit but required for the expression of functional COX and
functions in the maturation of the heme A prosthetic group of COX.
This protein is predicted to contain 7-9 transmembrane domains
localized in the mitochondrial inner membrane. A gene mutation,
which results in the substitution of a lysine for an asparagine
(N204K), is identified to be responsible for cytochrome c oxidase
deficiency. In addition, this gene is disrupted in patients with
CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP
(hereditary neuropathy with liability to pressure palsies)
deletion.
Background References:
- Chen, Z., et al. Oncogene 29(30):4362-4368(2010)
- Vitali, M., et al.Neural Transm 116(12):1635-1641(2009)
- Dassa, E.P., et al. EMBO Mol Med 1(1):30-36(2009)
- Veluthakal, R., et al. Diabetes 56(1):204-210(2007)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This COX10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-410 amino acids from the C-terminal region of human COX10.
NCBI Gene ID #:
1352
NCBI Official Name:
Protoheme IX farnesyltransferase, mitochondrial
NCBI Official Symbol:
COX10
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
49 kDa
Protein Accession #:
Q12887
Protein GI Number:
292495084
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
Q12887
User NOte:
Optimal dilutions for each application to be determined by the researcher.