GSTM5 Antibody
Code | Size | Price |
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PSI-56-608-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Fluorescence-activated cell sorting (FACS)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Further Information
Additional Names:
Glutathione S-transferase Mu 5, GST class-mu 5, GSTM5-5, GSTM5
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Background:
Cytosolic and membrane-bound forms of glutathione
S-transferase are encoded by two distinct supergene families. At
present, eight distinct classes of the soluble cytoplasmic
mammalian glutathione S-transferases have been identified: alpha,
kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a
glutathione S-transferase that belongs to the mu class. The mu
class of enzymes functions in the detoxification of electrophilic
compounds, including carcinogens, therapeutic drugs, environmental
toxins and products of oxidative stress, by conjugation with
glutathione. The genes encoding the mu class of enzymes are
organized in a gene cluster on chromosome 1p13.3 and are known to
be highly polymorphic. These genetic variations can change an
individual's susceptibility to carcinogens and toxins as well as
affect the toxicity and efficacy of certain drugs. Diversification
of these genes has occurred in regions encoding substrate-binding
domains, as well as in tissue expression patterns, to accommodate
an increasing number of foreign compounds.
Background References:
- Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)
- Yu, K.D., et al. Breast Cancer Res. Treat. 121(2):485-496(2010)
- Davila, S., et al. Genes Immun. 11(3):232-238(2010)
- Moyer, A.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(3):811-821(2010)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Immunogen:
This GSTM5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-43 amino acids from the N-terminal region of human GSTM5.
NCBI Gene ID #:
2949
NCBI Official Name:
Glutathione S-transferase Mu 5
NCBI Official Symbol:
GSTM5
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
26 kDa
Protein Accession #:
P46439
Protein GI Number:
67476963
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
P46439
User NOte:
Optimal dilutions for each application to be determined by the researcher.