CLCN7 Antibody
| Code | Size | Price |
|---|
| PSI-56-086-400ul | 400ul | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Rabbit Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunofluorescence (IF)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Storage:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Documents
Further Information
Additional Names:
H(+)/Cl(-) exchange transporter 7, Chloride channel 7 alpha subunit, Chloride channel protein 7, ClC-7, CLCN7
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
Background:
The product of this gene belongs to the CLC chloride
channel family of proteins. Chloride channels play important roles
in the plasma membrane and in intracellular organelles. This gene
encodes chloride channel 7. Defects in this gene are the cause of
osteopetrosis autosomal recessive type 4 (OPTB4), also called
infantile malignant osteopetrosis type 2 as well as the cause of
autosomal dominant osteopetrosis type 2 (OPTA2), also called
autosomal dominant Albers-Schonberg disease or marble disease
autosoml dominant. Osteopetrosis is a rare genetic disease
characterized by abnormally dense bone, due to defective resorption
of immature bone. OPTA2 is the most common form of osteopetrosis,
occurring in adolescence or adulthood.
Background References:
- Furthner, D., et al. Klin Padiatr 222(3):180-183(2010)
- Phadke, S.R., et al. Indian J. Med. Res. 131, 508-514 (2010) :
- Pangrazio, A., et al. Hum. Mutat. 31 (1), E1071-E1080 (2010) :
- Kajiya, H., et al. Pflugers Arch. 458(6):1049-1059(2009)
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Immunogen:
This CLCN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-720 amino acids from the C-terminal region of human CLCN7.
NCBI Gene ID #:
1186
NCBI Official Name:
H(+)/Cl(-) exchange transporter 7
NCBI Official Symbol:
CLCN7
NCBI Organism:
Homo sapiens
Physical State:
Liquid
PREDICTED MOLECULAR WEIGHT:
89 kDa
Protein Accession #:
P51798
Protein GI Number:
12644301
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Research Area:
Obesity,Signal Transduction
Swissprot #:
P51798
User NOte:
Optimal dilutions for each application to be determined by the researcher.